Study Shows Probiotic Strains Alter Cytokines Production

Q: What was the purpose of this study?

To examine how specific probiotics affect inflammatory and anti-inflammatory cytokines in obese rats.

Q: How was obesity induced in the rats?

Obesity was induced through neonatal administration of monosodium glutamate (MSG).

Q: What were the key findings?

Probiotics reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines, especially when used in combination.

Q: Why are these results important?

They suggest probiotics may help develop new treatments for obesity-related inflammation and metabolic disorders.

Summary: This study shows that specific probiotic strains reduce inflammation in rats with MSG-induced obesity. A combination of Lactobacillus casei and Bifidobacterium animalis lowered pro-inflammatory cytokines and increased anti-inflammatory markers, showing stronger effects than single strains and highlighting probiotics’ potential role in managing obesity-related inflammation.

The aim of this study was to investigate the effect of probiotic strains of Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, B. animalis VKB on the pro- and anti-inflammatory cytokines production in Wistar male rats with monosodium glutamate (MSG)-induced obesity. It was established that neonatal administration of MSG to rats leads to increasing levels of the interleukin (IL)-1β and IL-12, and to decreasing ofthe IL-4, IL-10 and tumor growthfactor (TGF)-β levels in the bloodserum. After administration of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition to obese rats the level of the IL-lP in blood serum wasn't differ from that in the obese rats, that didn't receive of the probiotic bacteria. But there was no statistically signifcant difference comparing with intact rats. The level of the IL-12B p4O in blood serum was decreased under influence of the B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition (18.9%, p < 0.05) and B. animalis VKL (10.5%, p < 0.05) compared with obese rats, not receiving probiotic bacteria, but remained higher than in intact animals. After administration to obese rats ofthe B. animalis VKL - B. animalis VKB - L. casei IMV B-7280 composition the levels ofthe IL-4, IL- 10 and TGF-β increased in blood serum comparing with obese rats, not receiving probiotic bacteria. The level of the IL-10 also increased under influence of the B. animalis VKB, and IL-4 - under influence of the L. casei IMVB-7280. Our results suggest that these probiotic bacteria and probiotic composition are able to down-regulation the inflammation in rats with MSG-induced obesity but the strongest anti-inflammatory effects have probiotic composition. The ability of lactobacilli and bifdobacteria to alter the pro- and anti-inflammatory cytokines production, opens perspectives to create new treatments for obesity and metabolic syndrome based on probiotics.

FAQ's

To examine how specific probiotics affect inflammatory and anti-inflammatory cytokines in obese rats.

Obesity was induced through neonatal administration of monosodium glutamate (MSG).

Lactobacillus casei IMV B-7280, Bifidobacterium animalis VKL, and B. animalis VKB.

Probiotics reduced pro-inflammatory cytokines and increased anti-inflammatory cytokines, especially when used in combination.

They suggest probiotics may help develop new treatments for obesity-related inflammation and metabolic disorders.

Study Shows Probiotic Strains Alter Cytokines Production

FAQ's

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